L1 mobile element expression causes multiple types of toxicity
نویسندگان
چکیده
منابع مشابه
The Human L1 Element Causes DNA Double-Strand Breaks in Breast Cancer
RNA interference has become a powerful tool for the specific inhibition of genes in mammalian cells. Previously, Alu-linked hairpins were demonstrated to transiently mediate RNA interference without associated toxicity in contrast to hairpins expressed from upstream RNA pol III promoters. To expand upon those results, we now demonstrate that hairpins attached to the ID portion of the rat neuron...
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[This corrects the article DOI: 10.1371/journal.pone.0183023.].
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BACKGROUND For non-small cell lung cancer (NSCLC), treatment with pembrolizumab is limited to patients with tumours expressing PD-L1 assessed by immunohistochemistry (IHC) using the PD-L1 IHC 22C3 pharmDx (Dako, Inc.) companion diagnostic test, on the Dako Autostainer Link 48 (ASL48) platform. Optimised protocols are urgently needed for use of the 22C3 antibody concentrate to test PD-L1 express...
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Background Programmed cell death-1 (PD-1) is a co-inhibitory receptor expressed on lymphoid and non-lymphoidderived cells that negatively regulates peripheral T-cell responses. PD-L1, the major PD-1 ligand, is expressed on various tumors and is being investigated as a possible predictive marker for anti-PD-1 therapy. Few studies have determined PD-L1 expression across tumor types using a consis...
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Hypersequents are nite sets of ordinary sequents. We show that multiple-conclusion sequents and single-conclusion hypersequents represent two diierent natural methods of switching from a single-conclusion calculus to a multiple-conclusionone. The use of multiple-conclusionsequents corresponds to using a multiplicative disjunction, while the use of single-conclusion hypersequents corresponds to ...
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ژورنال
عنوان ژورنال: Gene
سال: 2008
ISSN: 0378-1119
DOI: 10.1016/j.gene.2008.04.013